Which hormone inhibits both insulin and glucagon secretion?

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Multiple Choice

Which hormone inhibits both insulin and glucagon secretion?

Explanation:
Somatostatin acts as a brake on hormone release from the pancreatic islets. Secreted by delta cells, it inhibits both insulin from beta cells and glucagon from alpha cells, helping to fine‑tune glucose levels after meals. This suppression occurs in a paracrine fashion, with somatostatin binding to receptors on neighboring islet cells and reducing signaling that would otherwise drive insulin and glucagon secretion. The other options don’t have this dual inhibitory effect: amylin mainly slows gastric emptying and suppresses glucagon; T3 mainly affects overall metabolism; pancreatic polypeptide regulates exocrine function and other digestive processes.

Somatostatin acts as a brake on hormone release from the pancreatic islets. Secreted by delta cells, it inhibits both insulin from beta cells and glucagon from alpha cells, helping to fine‑tune glucose levels after meals. This suppression occurs in a paracrine fashion, with somatostatin binding to receptors on neighboring islet cells and reducing signaling that would otherwise drive insulin and glucagon secretion. The other options don’t have this dual inhibitory effect: amylin mainly slows gastric emptying and suppresses glucagon; T3 mainly affects overall metabolism; pancreatic polypeptide regulates exocrine function and other digestive processes.

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