Which glucose transporter does the liver use for glucose entry that is independent of insulin?

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Master the HCC1 Glucose Regulation Test with targeted questions and explanations. Enhance your preparation and boost your confidence for the exam!

Multiple Choice

Which glucose transporter does the liver use for glucose entry that is independent of insulin?

Explanation:
Glucose moves into liver cells through GLUT2, which is a high-capacity, low-affinity transporter that allows bidirectional flow of glucose depending on concentration. Because GLUT2 activity isn’t driven by insulin signaling, the liver can take up glucose and release it back into the blood regardless of insulin. This contrasts with GLUT4, which requires insulin to reach the cell surface in muscle and fat, and with GLUT1 or SGLT1, which don’t primarily govern physiologic hepatic glucose entry. So, the hepatic uptake of glucose in an insulin-independent manner is mediated by GLUT2.

Glucose moves into liver cells through GLUT2, which is a high-capacity, low-affinity transporter that allows bidirectional flow of glucose depending on concentration. Because GLUT2 activity isn’t driven by insulin signaling, the liver can take up glucose and release it back into the blood regardless of insulin. This contrasts with GLUT4, which requires insulin to reach the cell surface in muscle and fat, and with GLUT1 or SGLT1, which don’t primarily govern physiologic hepatic glucose entry. So, the hepatic uptake of glucose in an insulin-independent manner is mediated by GLUT2.

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